Pankaj Kapahi, PhD, Buck Institute for Research on Aging
The lab of Dr. Kapahi was the first to identify the role of mTOR (mammalian Target Of Rapamycin) in mediating life extension by caloric restriction.
TOR pathway: linking nutrient sensing to life
span
Kapahi P and Zid B.
Sci Aging Knowledge Environ. 2004 Sep 8;2004(36):PE34.
Recent studies point to an emerging role for the TOR (target of rapamycin) pathway in the regulation of life span. In this Perspective, we discuss the possibility that this pathway is an important modulator of nutrient-dependent changes in life span. Additionally, we discuss the interactions between the TOR and insulin-like signaling pathways as well as the key downstream processes that TOR regulates.
PMID: 15356349. NIH, NLM, PubMed access to MEDLINE's biomedical citations
Read more about Dr. Kapahi.
Now mTOR has emerged as one of the most important aging markers, and downregulating mTOR is an integral part of the CR Way to slowing aging, for example: mTOR discussion