The Calorie Restriction science presented in the CR Way provides the essential knowledge for you to begin your journey.  But breakthrough research continues daily and we encourage you to continue your exploration by learning to use PubMed.gov, Google Scholar, MedlinePlus.gov, Mendosa.com and other information resources and by joining the Calorie Restriction Society (www.CalorieRestriction.org). All of these resources will give you updates and help provide the depth of understanding necessary to make objective choices.

Here are some of the groundbreaking scientists who have influenced us and thousands of other CR practitioners:

Stephen Austad, Ph.D.: Deepened our understanding of the relationship of growth to aging, helping us remain wary of growth stimulating practices that may accelerate aging.

Andy Brawley, Ph.D., and Richard Lord, Ph.D., of Metametrix Laboratories gave us new insights into how nutrition affects health at the molecular level – ultimately helping us better evaluate how our CR practice works.

Haim Cohen of the Sinclair Lab showed the relationship between the insulin/IGF-I pathway and the energy-sensitive SIRT1 – helping us focus on the aspects of CR that can really make a difference in how fast we age.

Brian Delaney, ABD: Was a principal founder and developer of the Calorie Restriction Society, which provides invaluable input on all aspects of CR and Longevity. We’ve improved many of our lifestyle practices based on input from other Society members.

Joseph Dhahbi, M.D., PhD: deepened our understanding of genic and physiologic responses to calorie restriction, inspiring us to plan our diet to enhance these changes.

Luigi Fontana, M.D., Ph.D.: Created the first human studies on CR – providing a standard to judge our CR practice and valuable guidance on how to safely live a CR life.

L. Gan: Demonstrated the relationship between SIRT1 activity and IGFBP1 – giving us a means to test for SIRT1 activation clinically.

Leonard Guarente, Ph.D.: Heads the lab that discovered the function of SIR2 in aging –ultimately influencing how we plan our CR lifestyle 

Wei Gu, Ph.D.:  Discovered the relationship between the cancer protector p53 and SIRT1 – influencing us to moderate cell proliferating activities when our SIRT1 gene is likely to be expressed.

Shin Imai, MD, Ph.D.:  Helped us understand the relationship between SIRT1 and NAD – reinforcing the importance of keeping glucose low as part of the best way to practice CR.

John Holloszy, Ph. D.: Deepened our understanding of the role exercise plays in health and its limitation in slowing aging, resulting in our moderation of the amount of exercise we do each day. 

Cynthia Kenyon, Ph.D.:  Discovered the important influence of the insulin–IGF-I system on aging. We’ve eliminated foods that provoke insulin, independent of calories.

Ed Masoro, Ph.D.: His prolific writing gave us tools to understand CR physiology, helping us avoid lifestyle practices that counter our CR benefits.

Mark Mattson, Ph.D.: Discovered that time away from food is important for producing CR-related benefits, especially cognitive improvements. Dr. Mattson’s work influenced us to include a significant daily fasting period in our regimen.

Marty Mayo, Ph.D.: Demonstrated that activating SIRT1 also controls a central driver of inflammation, NF-kappaB, resulting in our paying close attention to how prevent activation of inflammation pathways. 

Roger McCarter, Ph.D.: Demonstrated the limitations of physical exercise and its role in calorie restriction, causing us to keep our exercise regimens moderate and focused on cell signaling.

Clive McKay, M.D.: Did the first major calorie restriction research on laboratory animals – 60 years later we began our CR practice.

Pere Puigserver, Ph.D.: Discovered SIRT1’s link to gluconeogenesis – helping us understand the importance of glucose control for longevity.

David Sinclair, Ph.D.: Helped us understand the pathways that must be activated for SIRT1 to be expressed. His work on Resveratrol is a leap forward in how a CR mimetic may be used for better health.

Christine Snow, Ph.D.: Proved that weight bearing exercise can prevent bone loss – influencing us to integrate exercise using weighted vests into our routine

Stephen Spindler, Ph.D.:  Especially renowned for genetic microarray work on calorie restricted animals, helped us understand that CR benefits can be quickly activated at any age.

Ted (Theodore B.) VanItallie, M.D.: Helped us understand the health benefits of ketones – influencing us to make ketones part of our CR practice.

Richard Veech, MD, Ph.D.: Deepened our understanding of ketones and the positive effect they may have on neurological disorders such as Alzheimer’s and Parkinson’s diseases.

Helen Vlassara, M.D.: In-depth research into advanced glycation endproducts influenced us to prepare foods in ways that minimize exposure to AGE.

Roy Walford, M.D.: His books and software helped us begin to live a CR lifestyle. His daughter Lisa continues his work.

Rick Weindruch, Ph.D.: Wrote first CR article that we read, showing us how humans could practice CR.

Brad Wilcox, Ph.D.: His detailed research on the Okinawan diet and lifestyle influenced food choices and macronutrients ratios for our diet.

*The CR Way

This entry was posted on Tuesday, November 18th, 2008 at 11:57 am and is filed under 1.LatestNews . You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.